Publications.

Highlighted manuscripts.

Hernandez et al., Genome Biology, 2023.

Here, we perform a multi-ancestry phenome-wide association study in 7789 children aged 9–12 years to examine the relationship between genetically regulated expression (GREx) of C4A, childhood brain structure, cognition, and psychiatric symptoms.

Hernandez et al., Biol Psych GOS, 2022.

Using data from the Adolescent Brain Cognitive Development Study, we assessed phenotypic relationships, heritability, and genetic correlations between childhood sleep disturbances (insomnia, arousal, breathing, somnolence, hyperhidrosis, sleep-wake transitions), brain size, and dimensional psychopathology.

Hernandez, Kim, et al., Biol Psych, 2021

Here, we discuss opportunities and challenges of high-throughput transcriptomic profiling in the human brain, and how transcriptomic approaches can help pinpoint mechanisms underlying genetic risk for psychiatric disorders at a scale necessary to tackle daunting levels of polygenicity.

All publications.

2023

Hernandez LM, Kim M, Zhang P, Bethlehem R, Hoftman G, Loughnan R, Smith D, Bookheimer SY, Fan CC, Bearden CE, Thompson W, Gandal M (2023). Multi-ethnic, phenome-wide association of C4 variation with longitudinal psychiatric and brain developmental phenotypes in youth. Genome Biology, 24(1):42.

Hernandez LM. Sex-differential neuroanatomy in autism: A shift toward male-characteristic brain structure (2023). American Journal of Psychiatry, 180(1):8-10.

Hernandez LM. Mapping the genetic and phenotypic landscape of neonatal C3 and C4 protein concentrations (2023). Cell Genomics, 3(12):100456.

Lawrence KE, Abaryan Z, Laltoo E, Hernandez LM, Gandal MJ, McCracken JT, Thompson PM (2023). White matter microstructure shows sex differences in late childhood: Evidence from 6797 children. Human Brain Mapping, 44(2)535-548.

Yap CX, Henders AK, Alvares GA, Giles C, Huynh K, Nguyen A, Wallace, L, McLaren T, Yang Y, Hernandez, LM, Gandal MJ, Hansell NK, Cleary D, Grove R, Hafekost C, Harun A, Holdsworth H, Jellett R, Kahn F, Lawson LP, Leslie J, Frenk ML, Masi A, Mathew NE, Muniandy M, Nothard M, Miller JL, Nunn L, Strike LT, de Zubicaray GI, Thompson PM, McMahon KL, Wright MJ, Visscher PM, Dawson PA, Dissanayake C, Eapen V, Heussler HS, Whitehouse AJO, Meikle PJ, Wray NR, Gratten J (2023). Interactions between the lipidome and genetic and environmental factors in autism. Nature Medicine, 929(4): 936–949.

Seidlitz J, Mallard TT, Vogel JW, Lee YH, Warrier V, Ball G, Hansson O, Hernandez LM, Mandal AS, Wagstyl K, Lombardo MV, Courchesne E, Glessner JT, Satterthwaite TD, Bethlehem RAI, Lifespan Brain Chart Consortium, Tasaki S, Ng B, Gaiteri C, Smoller JW, Ge T, Gandal MJ, Aaron F. Alexander-Bloch AF (2023). The molecular genetic landscape of human brain size variation. Cell Reports, 42(11):113439.

2022

Hernandez LM, Kim M, Hernandez C, Thompson W, Fan CC, Galvan A, Dapretto M, Bookheimer SY, Fuligni A, Gandal M (2022). Decoupling sleep and brain size in childhood: An investigation of genetic covariation in the ABCD study. Biological Psychiatry: Global Open Access, 3(1):139-148.

2021

Kim M, Haney JR, Zhang P, Hernandez LM, Wang L, Perez-Cano L, Loohuis LMO, de la Torre-Ubieta, Gandal M (2021). Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia. Nature Neuroscience, 24:799-809.

Lawrence KE, Hernandez LM, Fuster E, Padgaonkar NT, Patterson G, Jung J, Okada NJ, Lowe JK, Hoekstra JN, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland J, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Geschwind DH, Dapretto M, on behalf of the GENDAAR Consortium (2021). Impact of autism genetic risk on brain connectivity: A mechanism for the female protective effect. Brain, 145(1):378-387.

2020

*Hernandez LM, *Kim M, Haney J, del la Torre Ubieta L, Pasaniuc B, Gandal MJ (2020). Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders. *Equal Contribution. Biological Psychiatry, 89(1):54-64.

Lawrence K, Hernandez LM, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Bookheimer SY, Dapretto M, on behalf of the GENDAAR Consortium (2020). Neural responsivity to social rewards in autistic female youth. Translational Psychiatry, 10(1):178.

Hernandez LM, Lawrence KL, Padgaonkar NT, Hoekstra JN, Lowe JK, Green SA, Geschwind D, Bookheimer SY, Dapretto M (2020). Imaging-genetics of sex differences in ASD: Distinct effects of OXTR variants on brain connectivity. Translational Psychiatry, 10:82.

Cummings KK, Lawrence KE, Hernandez LM, Wood ET, Bookheimer SY, Dapretto M, Green SA (2020). Sex difference in salience network connectivity and its relationship to sensory over-responsivity in youth with autism spectrum disorder. Autism Research, 13(9): 1489-1500.

Hernandez LM, Green SA, Inada M, Bookheimer SY, Dapretto M (2020). Social attention in autism: Neural sensitivity to speech over background noise predicts encoding of social information. Frontiers in Psychiatry, 11:343.

Bielczyk NZ, *Ando A, *Badhwar A, *Caldinelli C, *Gao M, *Haugg A, *Hernandez LM, *Ito K, *Kessler D, *Lurie D, *Makary MM, *Nikolaidis A, *Veldsman M, OHBM Student and Postdoc Special Interest Group (2020). Effective self-management for early career researchers in the natural sciences. *Equal Contribution. Neuron, 106(2):212-217.

Padgaonkar NT, Lawrence KE, Hernandez LM, Green SA, Galval A, Dapretto M (2020). Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth. Developmental Cognitive Neuroscience, 44:100797.

Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RS, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, on behalf of the GENDAAR Consortium (2020). Sex Differences among Youth with ASD in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks. Cerebral Cortex, 30(9):5107-5120.

2019

Vijayakumar N, Pfeifer JH, Flournoy JC, Hernandez LM, Dapretto M (2019). Affective reactivity during adolescence: Associations with age, puberty, and testosterone. Cortex, 117:336-350.

Green SA, Hernandez LM, Lawrence KL, Liu J, Tsang T, Yeargin J, Cummings K, Dapretto D, Bookheimer SY (2019). Distinct patterns of neural habituation and generalization in youth with autism, with and without sensory over-responsivity. American Journal of Psychiatry, 176(12):1010-1020.

2018

Green SA, Hernandez LM, Bowman H, Bookheimer SY, Dapretto M (2018). Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Developmental Cognitive Neuroscience, 29:127-139.

Sherman LE, Greenfield PM, Hernandez LM, Dapretto M (2018). Peer influence via Instagram: Effects on brain and behavior in adolescence and young adulthood. Child Development, 89(1):37-47.

Sherman LE, Hernandez LM, Greenfield PM, Dapretto M (2018). What the brain “likes:” Neural correlates of providing feedback on social media. Social Cognitive and Affective Neuroscience, 13(7):699-707.

Lawrence KL, Hernandez LM, Bookheimer SY, Dapretto M (2018). Atypical developmental trajectories of functional connectivity in autism spectrum disorder assessed longitudinally in adolescence. Autism Research, 12(1):53-65.

2017

Green SA, Hernandez LM, Bookheimer SY, Dapretto M (2017). Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Research, 10(5):801-809.

Hernandez LM, Krasileva K, Green SA, Sherman LE, Ponting C, McCarron R, Geschwind DH, Bookheimer SY, Dapretto M (2017). Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism. Molecular Psychiatry, 22(8):1134-1139.

2016

Sherman LE, Payton AA, Hernandez LM, Greenfield PM, Dapretto M (2016). The power of the “like” in adolescence: Effects of peer influence on neural and behavioral responses to social media. Psychological Science, 27(7):1027-1035.

Green SA, Hernandez LM, Bookheimer SY, Dapretto M (2016). Salience network connectivity in autism is related to brain and behavioral markers of sensory over-responsivity. Journal of the American Academy of Child and Adolescent Psychiatry, 55(7):618-626.

2015

Hernandez LM, Wang T, Dapretto M (2015). Neural correlates of social cognition deficits in autism spectrum disorders. In: Arthur W. Toga, editor. Brain Mapping: An Encyclopedic Reference, vol. 3, pp. 177-182. Academic Press: Elsevier.

Green SA, Hernandez LM, Tottenham N, Krasileva K, Bookheimer SY, Dapretto M (2015). The neurobiology of sensory over-responsivity in youth with autism spectrum disorders. JAMA Psychiatry, 72(8):778-86.

Jann K, Hernandez LM, Beck-Pancer D, McCarron R, Smith RX, Dapretto M, Wang DJJ. (2015). Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder. Brain and Behavior, 5(9):e00358.

2014

Hernandez LM, Rudie JD, Green SA, Bookheimer S, Dapretto M (2014). Neural signatures of autism spectrum disorders: Insights into brain network dynamics. Neuropsychopharmacology, 40(1):171-189.

Moses P, DiNino M, Hernandez LM, Liu TT (2014). Developmental changes in resting and functional cerebral blood flow and their relationship to the BOLD response. Human Brain Mapping, 35(7):3188-98.

Moses P, Hernandez LM, Orient E (2014). Age-related differences in cerebral blood flow underlie the BOLD fMRI signal in childhood. Frontiers in Psychology, 5:300.

2013

Green SA, Rudie JD, Colich NL, Wood JJ, Shirinyan D, Hernandez LM, Tottenham N, Dapretto M, Bookheimer SY (2013). Over-reactive brain responses to sensory stimuli in youth with autism spectrum disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 52(11):1158-72.

2012

Colich NL, Wang AT, Rudie JD, Hernandez LM, Bookheimer SY, Dapretto M (2012). Atypical neural processing of sarcastic and sincere remarks in children and adolescents with autism spectrum disorders. Metaphor and Symbol, 27:70-92.

Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto M (2012). Autism-associated promoter variant in MET impacts functional and structural brain networks. Neuron, 75(5):904-15.

Pfeifer JH, Merchant JS, Colich NL, Hernandez LM, Rudie JR, Dapretto M (2012). Neural and behavioral responses during self-evaluative processes differ in youth with and without autism. Journal of Autism and Developmental Disorder, 43(2):272-85.

Rudie JD, Brown JA, Beck-Pancer D, Hernandez LM, Dennis EL, Thompson PM, Bookheimer SY, Dapretto M (2012). Altered Functional and Structural Brain Network Organization in Autism. NeuroImage: Clinical, 2:79-94.

2011

Rudie JD, Shehzad Z, Hernandez LM, Colich NL, Bookheimer SY, Iacoboni M, Dapretto M (2011). Reduced functional integration and segregation of distributed neural systems underlying social and emotional information processing in autism spectrum disorders. Cerebral Cortex, 22(5):1025-37.